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One could also speculate that increased stress hormone activity (ie, catecholamines, cortisol) in the setting of anxiety or depression could have contributed to persistent hyperglycemia
Nat Protoc 1(6):3159 Rahman A, Mostofa MG, Nahar K, Hasanuzzaman M, Fujita M (2016) Exogenous calcium alleviates cadmium-induced oxidative stress in rice (Oryza sativa L.) seedlings by regulating the antioxidant defense and glyoxalase systems
Patient safety must always take precedence, and replacement doses can usually be arranged through the prescribing team or trial site